QT延長症候群を合併した肝硬変の2例

Abstract

Two cases of liver cirrhosis complicated with QT interval prolongation syndrome are reported. The first case was a 64-year-old female. She was admitted to our hospital because of pleural effusion and hypoalbuminemia, and diagnosed as having decompensated liver cirrhosis. DB-cAMP was administered for liver cirrhosis. Eighteen days later, QT interval prolonged and ventricular tachycardia occurred. Laboratory tests revealed hypopotassemia and hypocalcemia. The second case was a 76-year-old female. She had been treated with glycyrrhizin for liver cirrhosis since ten years before. She was admitted because of QT interval prolongation and ventricular tachycardia. Laboratory tests revealed hypopotassemia, hypocalcemia and hypomagnesemia. In both of these cases, electrocardiogram showed Torsades de Pointes and cardioversion were not effective. Torsades de Pointes returned to sinus rhythm by right ventricular pacing and correction of both hypopotassemia and hypocalcemia. Based on the study of these cases, it is concluded that electrocardiogram is sometimes necessary for the management of liver cirrhosis.