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01121 Journal of Nara Medical Association >
Vol.45 No.4 >

このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/10564/1643

タイトル: アルコールによるIMMUNE CIRCUIT増幅作用の解析
その他のタイトル: ANALYSIS OF ENHANCING EFFECTS OF IMMUNE CIRCUIT ELICITED BY ALCOHOL
著者: 東野, 正
キーワード: alcoholic liver diseases
IgA
Peyer's patch
polyclonal antibody production
immune circuit
発行日: 1994年8月31日
出版者: 奈良医学会
引用: 奈良医学雑誌 Vol.45 No.4 p.370-385
抄録: In order to acquire a better understanding of the precise mechanism of elevated serum IgA levels in patients with alcoholic liver diseases, the author investigated effects of alcohol (AL) on the immune circuit in C57BL/6 (high AL preference) mice and DBA/2 (low AL preference) mice. Short-term administration of AL elicited polyclonal antibody production in C57BL/6 mice, but not in DBA/2 mice. Long-term oral administration of AL, however, elicited polyclonal antibody production in the spleen and Peyer's patch of DBA/2 mice as well as C57BL/6 mice. When sheep red blood cells (SRBCs) were administered as an antigen, intraperitoneal injection of SRBCs induced stronger anti-SRBC responses than oral administration in both mice. After 1 month oral administration of AL, however, differences of anti-SRBC responses were not observed between intraperitoneal and oral administration. Moreover, after 4 months oral administration of AL, oral administration of SRBCs caused stronger anti-SRBC responses than intraperitoneal administration. Thus, long-term oral administration of AL altered the degree of immune responses that was caused by the difference of administration routes of the antigen. These results suggest that AL increased the permeability of antigens in the intestinal mucosal layer. Furthermore, it was demonstrated that long-term oral administration of AL activated T-cells and macrophages, and increased both Interleukin-1 and Interleukin-2 activity. These results indicate that AL acts as a low-molecular-weight polyclonal B-cell activator, and enhances polyclonal antibody production in the gut-associated lymphoid tissue such as Peyer's patch. Therefore, it is suggested that AL enhances the immune circuit, resulting in the increase of serum IgA levels in patients with alcoholic liver diseases.
URI: http://hdl.handle.net/10564/1643
ISSN: 04695550
13450069
出現コレクション:Vol.45 No.4

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