多彩な神経症状を呈した抗リン脂質抗体陽性の全身性エリテマトーデスの1例

Abstract

A case of systemic lupus erythematosus (SLE) with various neurological disorders related to anti-phospholipid antibodies (aPL) is reported. The patient was a 25 -year-old female, who had been diagnosed as having idiopathic thrombocytopenic purpura (ITP) at the age of 9, and SLE at the age of 11. A diagnosis of autoimmune hemolytic anemia (AIHA) was made at the age of 19. Three years later, she experienced numbness of arms and legs. Furthermore, two years later, she had movement disorders and high titers of aPL were revealed. Oral administration of prednisolone and cyclophosphamide was begun. Subsequently, intravenous cyclophosphamide pulse therapy was carried out. However, these therapies did not exert an effect on her neurological disorders and the titers of aPL. aPL, detected often in patients with SLE, may cause various neurological disorders through thrombus formation in cerebral vessels and/or have a direct influence on the nervous system.