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01 奈良県立医科大学 >
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0122 学位請求論文 >
01221 博士論文(医学) >
2023年度 >
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http://hdl.handle.net/10564/4350
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タイトル: | Pneumococcal meningitis in adults in 2014-2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan |
その他のタイトル: | 日本における小児PCV13導入後2014年-2018年の成人肺炎球菌性髄膜炎 |
著者: | Fujikura, Hiroyuki Chang, Bin Tamura, Kosuke Watanabe, Hiroshi Tanabe, Yoshinari Kuronuma, Koji Fujita, Jiro Oshima, Kengo Maruyama, Takaya Abe, Shuichi Kasahara, Kei Nishi, Junichiro Kubota, Tetsuya Kinjo, Yuki Serizawa, Yusuke Shimbashi, Reiko Fukusumi, Munehisa Shimada, Tomoe Sunagawa, Tomimasa Suzuki, Motoi Oishi, Kazunori Adult IPD Study Group |
キーワード: | Diseases Medical research Microbiology |
発行日: | 2022年2月 |
出版者: | Nature Portfolio |
引用: | Scientific Reports. 2022 Feb, vol.12, no.1, article no.3066 |
抄録: | We assessed the impact of the pediatric 13-valent pneumococcal conjugate vaccine (PCV13) on pneumococcal meningitis in adults in Japan in 2014–2018 by comparing epidemiological characteristics of adults with invasive pneumococcal disease with (n = 222) and without (n = 1258) meningitis. The annual incidence of pneumococcal meningitis in 2016–2018 was 0.20–0.26 cases/100,000 population. Age (p < 0.001) and case fatality rate (p = 0.003) were significantly lower in patients with meningitis than in those without meningitis. The odds of developing meningitis were higher in asplenic/hyposplenic or splenectomized patients (adjusted odds ratio [aOR] 2.29, 95% CI 1.27–4.14), for serotypes 10A (aOR 3.26, 95% CI 2.10–5.06) or 23A (aOR 3.91, 95% CI 2.47–6.19), but lower for those aged ≥ 65 years (aOR 0.59, 95% CI 0.44–0.81). PCV13 had an indirect effect on nonmeningitis, but its impact on meningitis was limited because of an increase in non-PCV13 serotypes. Of meningitis isolates, 78 (35.1%) and 3 (1.4%) were penicillin G- or ceftriaxone-resistant, respectively. We also confirmed an association of the pbp1bA641C mutation with meningitis (aOR 2.92, 95% CI 1.51–5.65). |
内容記述: | 権利情報:© The Author(s) 2022. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
URI: | http://hdl.handle.net/10564/4350 |
ISSN: | 2045-2322 |
DOI: | https://doi.org/10.1038/s41598-022-06950-w |
学位授与番号: | 24601甲第899号 |
学位授与年月日: | 2024-03-14 |
学位名: | 博士(医学) |
学位授与機関: | 奈良県立医科大学 |
出現コレクション: | 2023年度
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