インドメタシンが有効であった出血性肺浮腫の1成熟新生児例

Abstract

Indomethacin (prostaglandin synthetase inhibitor) is an agent used com- monly to promote the closure of patent ductus arteriosus (PDA) in premature infants. However, its usefulness and effectivenss for PDA in a term infant remain controversial. We report a 0-day-old boy with heamorrhagic lung edema assosiated with neonatal asphyxia. Wc considered that increased pulmonary blood flow through the PDA worsened heamorrhagic lung edema iri this patient. Therefore we administered indomethacin to constrict the PDA and decrease pulmonary haemorrhage. Pulmonary haemorrhage was improved after this treatment. We suggest that indomethacin may be effective for haemorrhagic lung edema even in term infants when the PDA is a factor worsening the haemorrhagic lung edema.